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Verder is het belangrijk om te vermelden dat de totale glutathionstatus niet alleen afhangt van de concentratie van vrij glutathion, maar ook van de verhoudingen tussen de gereduceerde (actieve) en geoxideerde vormen

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( B ) Under conditions of APAP overdose along with iron overload, the excessive cellular free iron reacts with mitochondrial reactive oxygen species (ROS) to induce lipid peroxidation (LPO) of membranes