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These include the conserved cysteine residues, necessary for the typical defensin disulfide-bond connectivity, an arginine and a glutamate residue, forming a conserved salt bridge [146, 147], and a highly conserved glycine residue, which is essential for correct folding [148]

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Glutathione works by neutralizing harmful molecules, also known as free radicals, preventing them from causing cellular damage

In addition, future investigations should emphasize the rational combination of ferroptosis and cuproptosis inducers with immune checkpoint inhibitors or immune modulators to remodel the tumor immune microenvironment

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