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In short, rapamycin has been successfully used for numerous medical applications, such as anti-inflammation, anti-immune rejection, anti-tumor, and anti-endothelial proliferation treatments, and it plays a key role in the treatment of many diseases

Nat Med 21:677687

10.1016/j.bcp.2016.03.026 Biochem

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These two facts are the same story, told from two different angles

The histopathology of the nasal mucosa after repeated dosing did not show any signs of inflammation or tissue necrosis suggesting that Pol/PC or Pol/PEO vehicles could function as safe nasal delivery carriers for plasmid DNA