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It leads to changes in the structure of skin matrix proteins, such as collagen and elastin, and consequently, to loss of skin elasticity and firmness, the formation of wrinkles, and pigmentation disorders (116118)

Data extraction and quality assessment The following data were extracted from the included RCTs: authors, year of publication, country of origin, sample size, duration of follow-up, route of L-carnitine supplementation, dose, mean age and proportion of male participants

Finally, the effectiveness and feasibility of targeting APOA4 and PCSK9 in clinical treatment remain to be demonstrated

10.1002/1878-0261.12917 78 PetracheI.NatarajanV.ZhenL.MedlerT

No contm: Acar, sal, amido, fermento, trigo, glten, milho, soja, ovo, leite, marisco ou conservantes

Free Radic Res 47:869880 Tsukamoto H, Lu SC ( 2001 ) Current concepts in the pathogenesis of alcoholic liver injury