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It inhibits NF-B pathway activation, reducing the production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF- [130, 131]

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It has higher incidence in Scandinavian populations, shares risk factors with Parkinsons disease and Alzheimers diseases and was associated with mutations in the lysyl-oxidase-like 1 (LOXL1) gene, and mutations in loci encoding CACNA1A, TMEM136, SEMA6A and other genes

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