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These findings underscore the impact of probiotics on mucus barrier integrity and intestinal health (62, 63)

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Concomitantly, the mitochondrial antioxidant enzymes superoxide dismutase (SOD2) and heme oxygenase-1 (HO-1) were elevated, suggesting an adaptive mitochondrial oxidative stress response ( Figure 4E )

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Differential Diagnosis The differential diagnosis of such lesions includes cellular blue nevus, blue nevus with hypercellularity, the heavily pigmented epithelioid cell nevus, and regressed melanoma with prominent melanophage accumulation