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Its therapeutic potential is being explored in the treatment of inflammatory diseases, such as arthritis and Crohns disease, as well as respiratory conditions like pulmonary hypertension and asthma (2)

In the SURMOUNT trials, night sweats were more common during dose escalation phases (when patients moved from 2.5 mg to 5 mg to 10 mg weekly injections) rather than at maintenance doses

Published mechanisms include upregulation of growth hormone receptor expression, promotion of angiogenesis via VEGF pathway activation, modulation of the nitric oxide system, and interaction with the dopaminergic and serotonergic systems in neurological models

Research has explored its role in cellular growth signaling, differentiation pathways, and IGF-1 receptor interaction mechanisms in laboratory models

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This finding indicates that several counter-ligands of NK cell-triggering molecules may be considered suitable targets for the elimination of MB cells in patients (162)