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Both can drastically limit drug concentrations in the GBM (58), as observed in clinical studies with disappointing results in GBM patients, despite promising preclinical data (59, 60)

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Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1

Additionally, 164 miRNA expression abnormalities have been linked to sperm function deficits (105), creating a complex molecular signature of EED-induced damage