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Another study systematically evaluated the influence of PEG molecular weight, architecture, and conjugation chemistry on peptide delivery efficiency and cytotoxicity, revealing that these parameters critically affect the performance of PEGylated peptides

2019;316:L407L417

TB-500s biological activity is mediated primarily through binding of the LKKTETQ actin-binding motif to G-actin and sequestering actin monomers, regulating actin polymerisation dynamics, and activating downstream signalling through the PI3K/Akt pathway that promotes cell survival, migration, and proliferation in multiple cell types relevant to tissue repair including endothelial cells, fibroblasts, keratinocytes, and myocytes