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If such a vicious cycle of glutamate excitotoxicity, oxidative stress, and mitochondrial dysfunction does indeed underpin ME/CFS pathology, it may not be clear where exactly the root problem lies

J Psychopharmacol 35(12):14641472 Fernndez A, Rodriguez-Palancas A, Lpez-Ibor M et al (2005) Increased occipital delta dipole density in major depressive disorder determined by magnetoencephalography

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Multi-omics approaches, such as metabolomics to identify lipid peroxidation profiles and genomics to characterize polymorphisms in ferroptosis-regulating genes, may allow more accurate pathological classification

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