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Im not sure if its related, but the timing seems to coincide. While the exact mechanism behind the link between glutathione and headaches is not yet fully understood, it is thought to be related to changes in blood flow and intracranial pressure

To interrogate the mechanisms underlying NRF2-directed regulation of this core gene set, we compared mean promoter (1 kb restricted) ChIP-seq signal in A549 for NRF2, p300, as well as the histone marks H3K4me3 and H3K27ac, which are enriched at promoters and enhancers, respectively

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