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As with fetal glucocorticoids, postnatal glucocorticoids or stress can alter synaptic pruning and can also lead to reduced GR expression in brain regions important for glucocorticoid negative feedback, the hypothalamus and hippocampus ( These effects of the perinatal environment on GR can be imposed long-term via changes to the epigenome

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The pharmaceutical formulation of claim 28 comprising from about 0.1% (w/w) to about 10% (w/w) of azlocillin