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Nature 473 , 97100 (2011)

Retrieved July 23, 2021, from A, L., P, S., P, S., D, P., B, G., F, L., M, S., A, A., & L, G

44,45 Even after acclimatization to altitude hypoxia, individuals with PFO exhibited poorer gas exchange efficiency and a more blunted ventilatory response

3.3 Syndromes caused by mtDNA large-scale deletions 3.3.1 Mitochondrial DNA depletion syndrome (MDS) Mitochondrial DNA depletion syndrome (MDS) is a group of severe, phenotypically heterogeneous, recessively inherited disorders characterized by marked reduction of the mtDNA content leading to impaired energy production in the affected organs