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Indeed, in CLL, oxidative stress is present early in the genesis of disease and is detectable at the stage of pre-malignant monoclonal B-lymphocytosis.46 Thus to avoid the selection of adverse subclones with ATM-deficiency that occurs with conventional genotoxic agents,87 it is preferable to target stress phenotypes common to all tumor cells and, as in this case, potential mechanisms of diversification.47 Furthermore, elevated oxidative stress may provide a selective advantage for ATM-null CLL cells regarding their interactions with immune cells within lymphoid tissues

Coenzyme Q10 Coenzyme CoQ10 (CoQ10) plays an important role in preventing lipid peroxidation and protecting tissues against oxidative damage

J., Dolan, S

Patel, ST, Patil, S, Chamberlain, RS

Sevoz C, Rousselle C, Benot E, Buronfosse T