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doi: 10.1021/jf00084a050 59 SagatysDSDahlgrenCSmithGBottRCWhiteJM

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The compound has been studied across multiple tissue contexts (tendon, ligament, muscle, gastrointestinal, vascular)

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Mild side-effects like heartburn and indigestion are possible, and I usually keep the dose to around 2 grams a day

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Flow cytometric monitoring of constitutive MAPK phosphorylation and of pharmacodynamic MEK/MAPK inhibition in primary AML samples

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In the absence of SIRT4, a failure to undergo cell cycle arrest induced by DNA damage causes a delay in DNA repair and increased chromosomal instability, suggesting a tumor suppressor effect of SIRT4 151

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