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The Pcob specific C-terminal five-helix globin domain does not contribute directly to the dimer interface, and is positioned such that it forms interactions with both of the B 12 -binding domains (i.e., Rossmann fold and four-helix bundle)

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In animals, atractylodes administered at high doses has been shown to inhibit CYP3A1 activity, which is a homolog to the human CYP3A4 enzyme

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doi: 10.1002/bjs.1800801035