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Munc13-4 polymorphism is associated with MAS, sJIA and systemic inflammation, while chronic TLR9 stimulation in mice develops features characteristic of MAS, including elevated serum levels of IFN, interleukin 6 (IL-6) and hepatic inflammation 10

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Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding

Novel strategies like caspase-3-cleavable linkers create amplification loops where apoptosis triggers extracellular ADC cleavage (45)

Studies have shown that administering GLP-1 or leptin to obese individuals can reduce food intake and body weight

doi: 10.1186/s12974-017-1026-z 112 HamilosD