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In conclusion, as shown in the figure (Figure 8), this study identified MKL-1 as a negative regulator of ferroptosis

A similar pattern was observed in GPx enzyme activity

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By contrast, atypical 2-Cys PRDXs form an intramolecular disulfide intermediate by reacting the amino-terminal sulfenic acid (Cys-47) with a carboxy-terminal Cys-SH (Cys-151) of the same molecule that is able to be reduced by thioredoxin (27)