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Most importantly, the FDA has used this Special Controls document to misinterpret the learned intermediary doctrine

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Senescent cells perpetuate damage via the senescence-associated secretory phenotype (SASP)a pro-inflammatory secretome comprising cytokines (e.g., IL-6, TNF-), chemokines, and matrix-remodeling factors (Mei and Zheng, 2009)

doi: 10.1097/MIB.0000000000001004

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Vsquez N, Cervantes M, Bernal-Barragn H, Rodrguez-Tovar LE, Morales A (2022) Short-and long-term exposure to heat stress differently affect performance, blood parameters, and integrity of intestinal epithelia of growing pigs