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The gill, being in direct contact with water, are highly susceptible to environmental contaminants, while the liver, as the organ responsible for xenobiotic, is sensitive to toxic exposure and metabolism changes 33,34

These processes lead to apoptosis and necrosis of PTCs, thereby aggravating renal injury and promoting AKI progression (Sun et al., 2020)

Bioanalytical method validation

Current treatment approaches, including hormonal suppression and surgical excision, provide only temporary relief and are associated with systemic side effects, functional limitations, and high recurrence rates

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Campbell, A.M