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Intratumor heterogeneity: the rosetta stone of therapy resistance

We believe in science-forward formulations that respect the biology of the human body

18 mTORC1 integrates signals from nutrients and growth factors to regulate various anabolic processes, including protein synthesis, nucleotide production, lipid biosynthesis, and glycolysis, while inhibiting catabolic processes such as autophagy by phosphorylating ULK1/2 and sequestering lysosomal enzymes

10.1007/s10522-024-10099-6 68 XuY.LiuX.GuanJ.ChenJ.XuX

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Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging