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Also, after treatment of this cell line with the Akt inhibitor, MK2206 or the mTOR inhibitor (rapamycin) reduced the expression of Vimentin and SLUG (as EMT biomarkers)

Hypothesis: Thanks to a stronger weight loss, CagriSema should lead to a superior reduction of MACE compared to Semaglutide in SELECT (where Semaglutide reduced MACE by 20 %)

Unknown Long-Term Effects : Long-term risks remain unclear because controlled human studies have not established durable safety outcomes, organ effects, cancer-related concerns, or interaction risks