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A major problem with off-lattice models is that checking for one cells interactions amongst all other cells becomes extremely computationally inefficient as the number of cells increase

The ventrolateral PFC is also often referred to as the lateral orbital PFC

During the first one, participants filled in self-reports and were tested with the MoCA questionnaire and a battery of Executive Functions ( cognitive integrity evaluation)

doi: 10.3389/fphar.2025.1615681 Received 23 May 2025 Accepted 14 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Eoin Daniel OSullivan, Royal Brisbane and Womens Hospital, Australia Reviewed by Prerna Kumar, Tulane University, United States David Baird, University of Edinburgh, United Kingdom Sumaya Akter, Noakhali Science and Technology University, Bangladesh Saswat Kumar Mohanty, Brown University, United States Updates Copyright 2025 Zhang, Ni, Lin, Wang, He, Yuan, Han and Zuo

Alterations in systemic metabolic and inflammatory states can promote endothelial cell dysfunction, reducing the integrity of the BBB and potentially allowing peripheral blood factors to leak into the CNS compartment

Recently, a study involving human subjects found that elevated serum ferritin levels in liver donors were associated with a significant higher risk of liver damage in transplantation recipients [76], and blocking ferroptosis with compounds such as Fer-1, -tocopherol, and DFO prevented hepatic IRI [76]