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The Cost of Tobacco Use how many people die from smoking cigarettes a year Australia's biggest killer: smoking causes 66 deaths Throughout the entire 20th century, about 100 million people died earlier than they would have because of smoking. That's a lot, but it pales in comparison to the expected numbers for this More than 490,000 people in the U.S. die from cigarette smoking or secondhand smoke exposure each year. Learn how we can end tobacco disparities in the new Surgeon Generals Report from Dr. Vivek Tobacco and nicotine How Many People Die From Smoking? Tobacco Chart (2026)

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