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After six weeks of weekly treatments, skin biopsies revealed that the microdermabrasion serum side had increased skin thickness and fibroblast density (fibroblasts make collagen, per the National Cancer Institute), and antioxidant levels increased by 32 percent

Enhanced collagen production and accumulation by smooth muscle cells

The apoplast, a critical site for host-pathogen interactions, benefits from extracellular or apoplastic GPXs that reduce ROS levels, thereby helping the plant prevent tissue damage (Parish, 1971

4.1.4 FH Fumarate hydratase (FH) is a key enzyme involved in the TCA cycle that catalyzes the reversible interconversion of fumarate to malate via hydration and dehydration

This reaction depends on the catalytic selenocysteine residue of GPX4, which is directly targeted and inactivated by ferroptosis inducers such as RSL3

10.1016/j.bcp.2024.116603 284 Perez OrtizJ