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To reach their full anti-cancer potential, cytotoxic agents like doxorubicin, epirubicin, paclitaxel, docetaxel, cisplatin, carboplatin, antimetabolites, 5-fluorouracil, capecitabine, and targeted therapies like trastuzumab and CDK4/6 inhibitors rely on precise dosing or predictable metabolic pathways, among other factors (201)

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15,16 RS Epidemiology RS is a rare disorder inherited in an autosomal recessive digenic manner, requiring biallelic pathogenic variants in both SLCO1B1/1B3 genes

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