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A dense plasma-lymphocytic infiltrate in the portal tracts with interface hepatitis is a hallmark of chronic AIH, observed in 8090% of cases in both adult and pediatric cohorts [4, 60,61,62,63]

The strong interactions between METTYRTRP, observed through partial correlation networks at baseline confirms the connection between folate-mediated methionine formation, leading to methyl donation reactions that form the monoamine neurotransmitters serotonin, dopamine, and epinephrine 81,82

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Dopaminergic and glutamatergic pathways Alterations in dopaminergic and glutamatergic signaling have been demonstrated predominantly in in vivo rodent models following intraperitoneal MG administration

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