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Growth hormone secretagogue (GHRH analog) vs Growth hormone secretagogue (GHRH analog)

These combinations of peptides are designed to synergistically promote muscle hypertrophy, improve recovery, and optimize overall body composition

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Why that selectivity exists at the receptor level isnt entirely settled it may reflect biased agonism, where the specific binding geometry favors the somatotroph signaling pathway over the corticotroph one, even though both cell populations express GHSR-1a

In one small proof-of-principle physiology study, untreated hypogonadal men had an intact IGF1 response to GH stimulation, and this response was unchanged by cross-over treatment with both testosterone and dihydrotestosterone administered as transdermal gel (Veldhuis et al., 2009)

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