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doi: 10.1038/nrclinonc.2018.29 130 LuoBZhangSTanDYuXLinJWangM

It is investigational an FDA filing is under review but no regulator has cleared it and these figures are research reference data only, not clinical guidance

These bioactive metabolites serve dual functions as bioenergetic substrates for neuronal ATP synthesis and as regulators of redox homeostasis and neurogenic pathways

179,180 Red cells contain L-hexonate dehydrogenase, an enzyme that has the capacity to reduce aldoses such as glucose, galactose, or glyceraldehyde to their corresponding polyol (i.e., glucose to sorbitol, galactose to dulcitol, and glyceraldehyde to glycerol)

Lai Q, Liu FM, Rao WL, et al