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The pathophysiologically relevant mutations mainly occur in the region of the APP gene that encodes for the recognition sequences of the secretase proteases

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo

FoxO factors can also extend the lifespan in C

The three sgRNAs were cloned into pLENTICRISPR V2 backbone (RRID: Addgene_140206)

Enterotoxins of E

Upon activation, CueR induces transcription of at least 11 genes, including flcABCDE (PA3515-PA3519), copA, copZ, and mexPQ-opmE (PA3521-PA3523) (Teitzel et al