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Injectable routes typically provide more consistent systemic exposure and may be preferred for non-gastrointestinal applications requiring tissue delivery beyond the digestive tract

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Carcinogenesis, Mutagenesis, Impairment of Fertility Long term studies in animals to evaluate carcinogenic potential have not been done

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This raises the possibility that the DA synthesized by - and -cells also locally activates -cell D2R to inhibit SST secretion and thus removes SST-mediated inhibition of insulin and glucagon release 32,91,93,94,95,96,97,98