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Most patients begin to notice changes in body composition, energy, or recovery within 46 weeks, though optimal results are typically seen after 812 weeks of consistent use, alongside healthy lifestyle habits

Scale Weight: While less informative than body composition, weekly weigh-ins (same day/time, fasted) establish trends

Without adequate B12, youre also more likely to experience symptoms like chronic pain, depression, and fatigue, each of which makes it harder to get the physical activity you need to drop extra pounds and keep weight gain at bay

Studies demonstrate that NNMT inhibition "enhances fasting blood glucose levels, glucose tolerance, and insulin sensitivity" while reducing triglycerides and decreasing lipid deposition

My internist, Sabena Toor, straddles that divide

References Neelakantan, H., Vance, V., et al