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Fatty Acids and Lipid Metabolism Lipid metabolism is necessary to activate receptors, signal transduction and, modulation for maintaining several biological functions, including cognition (Yadav and Tiwari 2014)

The biological rationale for this category - and the one the brand leans on - is that L-Arginine and L-Citrulline serve as substrates for endothelial nitric oxide synthase (eNOS), the enzyme that produces nitric oxide in vascular tissue

In a small clinical trial in patients with breast cancer taking tamoxifen 20-30 mg daily, adding curcumin 1200 mg plus piperine 10 mg three times daily reduces the 24-hour area under the curve of tamoxifen and the active metabolite endoxifen by 12.8% and 12.4%, respectively, as well as the maximum concentrations of tamoxifen, when compared with tamoxifen alone

PMID: 33670839

MitoQ was found to induce mitochondrial damage in mouse kidney cortex tissue (78), although the concentrations used were much higher than the typical dosage used for cancer cells