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The Th cell subgroups mainly consist of Th1, Th2, and Th17 cells, which play an active role in both cellular and humoral immunity by secreting unique cytokines specific to their distinct functions [86]

Proc Natl Acad Sci U S A (2009) 106(2):5705

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In another study using HT22 cells, huperzine A (HupA) + wortmannin treatment stopped the downregulation of p-mTOR, p-Akt, and p-p70s6 kinase under oxidative glutamate toxicity, leading to the conclusion that HupA abrogates oxidative glutamate toxicity in mouse hippocampal cells via the activation of the BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway 51