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In a physiological state, PERK, IRE1, and ATF6 are non-covalently bonded to glucose-regulated protein 78 (GRP78)

Following PDT-induced ROS formation, EIpro not only triggers ICD to release tumor-associated antigens but also degrades EGFR, resulting in PD-L1 downregulation and enhanced anti-tumor immunity against both primary and metastatic illness

10.1016/j.cmet.2021.10.016 17 DalyE

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