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Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation

To strengthen this link, we employed small interfering RNAs (siRNAs) for GSH-metabolic enzymes to modulate GSH levels in our cell lines

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DOI: 10.1016/S0140-6736(21)01324-6 [2] Jastreboff, A.M., Aronne, L.J., Ahmad, N.N., et al

NO-induced dose-responsive DNA strand breakage and deaminations of cytosine to uracil and 5-methylcytosine to thymine account for the mutagenicity of nitric oxide toward bacteria and mammalian cells [5]