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The loss of induction of the -glutamyl cysteine synthase-light subunit (GCS-LS) is considered to be the responsible factor for loss of liver GSH level even under ethanol treatment [70]

[109] China [edit] The Chinese patent was scheduled to expire in 2026, but a court ruled in 2022 that all patents on semaglutide were invalid "for reasons related to experimental data availability"

JMIR Diabetes 7 , e23243 (2022)

Epigenetic modifications refer to chemical alterations, such as DNA methylation and histone modifications, that regulate gene expression without changing the underlying DNA sequence [168]