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Interpretation of reduced response to treatment can be complicated by regional differences in parasite populations, level of use of drugs and production practices, and context-specific surveillance becomes particularly relevant (113115)

Cisplatin exerts its cytotoxic effects through a complex interplay of molecular mechanisms, primarily by coordinating DNA to form platinumDNA adducts, resulting in DNA damage, mitochondrial dysfunction, reactive oxygen species (ROS) generation, modulation of cell death pathways and subsequent apoptosis [7]

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