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6e, all three GSSG-enhancing chemicals increased the levels of IKK--SSG adducts, suggesting that GSSG accumulation restrained IKK- activity by promoting IKK- S -glutathionylation, leading to subsequent NF-B suppression

doi: 10.1007/s10096-016-2881-8 24 TilgHAdolphTEGernerRRMoschenAR

Its broad biological actions reinforcement of epithelial barrier integrity, modulation of immune and inflammatory pathways, and beneficial effects on gut microbial composition provide a strong mechanistic rationale for its clinical application