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In a broad variety of cancers, GSTs are involved in the resistance to several anticancer drugs by their conjugating activity (some examples are reported below)

& Selker, E

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Figure 2 visually integrates this framework, illustrating both the common pathways (e.g., mitochondrial dysfunction, gutliver axis disruption) and their disease-specific manifestations, while emphasizing the bidirectional interplay between liver pathology and magnesium homeostasis