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explored the different binding modes of the pyrimidinone scaffold through cocrystal structures of cpds

Chauveau P, Chadefaux B, Coud M, Aupetit J, Hannedouche T, Kamoun P, et al

Iron-chelating and ros-scavenging polymers with thioketal and thioether bonds delivering ferroptosis inhibitor lip-1 provide a triple therapeutic strategy for retina ganglion cells in acute glaucoma

When detox pathways are overloaded, everyday exposures, from food, environment, or internal metabolism can pile up

Glutathione plays a central role in the bodys antioxidant defense systems and helps support cellular protection and normal detoxification processes

To investigate their biogenesis, we perform cryo-electron microscopy and liposome tubulation assays, showing that Arabidopsis SNX1 generates shorter membrane tubules than its mammalian counterpart, consistent with reduced membrane affinity linked to differences in the amphipathic helix