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HIF-1 protects against oxidative stress by directly targeting mitochondria

The authors gratefully acknowledge the support of the JHU-TRAC development award grant for covering the publishing cost of the minireview

To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)

With its established safety profile, Raloxifene and bazedoxifene, known for its dual estrogenic and anti-estrogenic effects, have demonstrated efficacy in clinical trials, significantly reducing the severity of melasma lesions compared to baseline measurements

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