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In ATP deficiency, AMPK is activated and blocks ferroptosis by inhibiting acetyl-CoA conversion to malonyl-CoA (the precursor of PUFA synthesis), mediated by acetyl-CoA carboxylase (ACC)

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A review published in the Journal of the International Society of Sports Nutrition highlighted that creatine can enhance fat-free mass gains and strength improvements, particularly when paired with a structured training program

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Elbostany EA, Elghoroury EA, Thabet EH, Rashad AA, Rasheed EA, El-Saeed GS, Abdelhalim DA, Abdelfattah SN, Salama II, Salama N (2023) Oxidative stress and hepcidin expression in pediatric sickle cell anemia with iron overload