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doi: 10.3389/fphar.2025.1566674 Received 25 January 2025 Accepted 18 August 2025 Published 04 September 2025 Volume 16 - 2025 Edited by Carlos Alan Dias-Junior, So Paulo State University, Brazil Reviewed by Yi Li, China Pharmaceutical University, China Antonietta Franco, Humanitas University, Italy Updates Copyright 2025 Hou, Lan, Li, Wang, Zheng, Wang, Xiong, Wang, Shi and Dong

Specifically, sphingomyelinases (also known as sphingomyelin phosphodiesterases) catalyze the cleavage of sphingomyelin, generating phosphocholine and ceramide

Key Takeaways Spinach is a nutrient-dense leafy green packed with vitamins A, C, and K1, plus minerals like iron, calcium, and folic acid

In fact, POMC and AgRP neurons modulate autonomic nerve activity in various tissues, including fat depots 34 , and these neurons can regulate fasting-induced fall in leptin levels, independently of changes in fat mass 35