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Notably, these alterations occur prior to the onset of inflammation and induce the upregulation of epithelial-derived cytokines such as thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33), which subsequently activate the Th2 immune axis in a sustained manner (Dai et al., 2022)

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From the most common to the least common, they include [23]: Injection site reactions, like pruritus, rash, pain, and swelling (3.1%) Arthralgia (2.4%) Pain in the extremities (1.1%) Myalgia (1.1%) Peripheral edema (1.1%) Paresthesia (0.9%) Hypoesthesia (0.7%) Rash (0.7%) Dysepsia (0.3%) Muscle pain (0.3%) Pruritus (0.3%) Vomiting (0.3%) Muscle stiffness (0.3%) Carpal Tunnel Syndrome (0.2%) Joint swelling (0.2%) Night sweats (0.2%) Palpitations (0.2%) Use in Specific Populations In addition to the adverse effects listed above, researchers must be extra cautious when administering tesamorelin to test subjects in the following populations: Individuals with hypothalamic-pituitary axis issues

Figure 2 S100A2 is a member of the S100 EF-hand calcium-binding family found in mammary epithelial cells and other organs or tissues, including the lungs, kidneys, liver, and prostate gland (44)

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