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Polarization was also assessed at the ultrastructural level, revealing features of primary liver tissue, including epithelial cells lining luminal structures arranged in a layer and connected by tight junctions, a feature of the hematobiliary barrier (Fig

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SIRT1 induces the circadian transcription of core clock genes, such as Cry1, Per2, Ror, and Bmal1 via either rhythmically deacetylating BMAL1 or PER2

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