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Although intestinal inflammation is typically associated with PFCD, endoscopic activity is absent in 10%-15% of patients during initial presentation

Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401- MITSUBA)

(2024) 8(8):bvae126

[223] designed a fluorescent probe by covalently coupling coumarin 343 (fluorophore) and 3-nitrophenylazanyl ester to visualize the activation of M1 and M2a macrophages by monitoring LIP levels via a photoinduced photon transfer mechanism induced by Fe(II)-activated NO bond cleavage

Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6

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