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This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

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10.2147/HP.S202775 131 SongQ.ChenY.WangJ.HaoL.HuangC.GriffithsA.et al (2020)

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