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Our research group investigated the apparent drivers of the increased production and excretion of proline by cells expressing an oncogenic mutant form of the enzyme, isocitrate dehydrogenase 1 (IDH1), which is regularly observed in grade II and III gliomas and around 10% of grade IV gliomas (glioblastomas)

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A total of 30 patients from five independent medical centers were enrolled in the study and received Theracurmin, an orally administered formulation containing 360 mg/day of curcumin, or a placebo for a duration of 12 weeks