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Research shows that nicotine activates nAChRs on dopaminergic neurons, which are crucial for regulating neurotransmitter release and neuronal excitability (Quik et al., 2008)

A randomized, double-blind, controlled trial comparing rifaximin plus lactulose with lactulose alone in treatment of overt hepatic encephalopathy

Despite their proliferative arrest, senescent cells exhibit a metabolically active state characterized by an altered glycolytic flux, perturbed lipid homeostasis, mitochondrial dysfunction, and a disrupted nicotinamide adenine dinucleotide (NAD +) redox balance, all of which contribute to vascular damage

They play many roles such as modulation of cell proliferation and differentiation, cell-matrix adhesion and assembly

Although chemotherapy may induce CIPN via various pathways, the main characteristics are inflammation and neuronal necrosis